Characterization of a hybrid dielectrophoresis and immunocapture microfluidic system for cancer cell capture
نویسندگان
چکیده
منابع مشابه
Characterization of a hybrid dielectrophoresis and immunocapture microfluidic system for cancer cell capture.
The capture of circulating tumor cells (CTCs) from cancer patient blood enables early clinical assessment as well as genetic and pharmacological evaluation of cancer and metastasis. Although there have been many microfluidic immunocapture and electrokinetic techniques developed for isolating rare cancer cells, these techniques are often limited by a capture performance tradeoff between high eff...
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The isolation of circulating tumor cells (CTCs) from cancer patient blood is a technical challenge that is often addressed by microfluidic approaches. Two of the most prominent techniques for rare cancer cell separation, immunocapture and dielectrophoresis (DEP), are currently limited by a performance tradeoff between high efficiency and high purity. The development of a platform capable of the...
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Microfluidic systems for affinity-based cell isolation have emerged as a promising approach for the isolation of specific cells from complex matrices (i.e., circulating tumor cells in whole blood). However, these technologies remain limited by the lack of reliable methods for the innocuous recovery of surface captured cells. Here, we present a biofunctional sacrificial hydrogel coating for micr...
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201 Hadi Shafiee, John L. Caldwell, and Rafael V. Davalos* Department of Engineering Science and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, VA Bioelectromechanical Systems Laboratory, Institute for Critical Technology and Applied Science (ICTAS), Virginia Polytechnic Institute and State University, Blacksburg, VA Bradley Department of Electrical and Computer Eng...
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Manipulation of biological cells using a CMOS/microfluidic hybrid system is demonstrated. The hybrid system starts with a custom-designed CMOS (complementary metal-oxide semiconductor) chip fabricated in a semiconductor foundry. A microfluidic channel is post-fabricated on top of the CMOS chip to provide biocompatible environments. The motion of individual biological cells that are tagged with ...
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ژورنال
عنوان ژورنال: ELECTROPHORESIS
سال: 2013
ISSN: 0173-0835
DOI: 10.1002/elps.201370191